I've been playing it on a 3-in-1 for the last 2hrs. Just flash it to NOR, any ROM over 15MB needs to be flashed to NOR memory. I'm using an old 3-in-1 that i got way before the new revision was released, which maybe slightly faster than the new versions. I haven't experienced any issues, where as some people on the GBAtemp forums seem to be complaining of slowdown, and freezes when opening the map using a 3-in-1, neither has happened to me yet.

I flashed it using the CycloDS Evo built in GBA loader, which is basically the same as GBA Exploader, but the slot-1 card shouldn't even matter. Anyway, if you flash the patched ROM to NOR memory you can play it on the DS.